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Asthma is a common disease in the general population. The aim of this study was to describe the prevalence of asthma and its impact on the health status of individuals in the general population of the city of Aracaju, Northeast Brazil. This study was conducted in the cities of Patos and Aracaju, located in the state of Sergipe. A random sample of 2,203 individuals, aged 15 to 74 years, was selected. The prevalence of asthma was estimated using the International Study of Asthma and Allergies in Childhood criteria. The health status was measured using the Medical Outcomes Study 36-Item Short Form Health Survey. Prevalence was computed by gender and age group. A logistic regression model was used to evaluate asthma as a risk factor for severe health problems. The prevalence of asthma was 8.8% (95% confidence interval: 8.0-9.6). A higher prevalence of asthma was observed among the population who had at least one severe health problem, compared to those who had no severe health problem (22.1% vs. 2.2%; pEvaluation of the cardiotoxicity of tamoxifen.
Tamoxifen (TMX) is a compound that has emerged as a successful treatment of hormone dependent breast cancer. It has been observed that rats and mice are more susceptible than are humans to the deleterious effects of this compound. In this study, the cardiac effects of TMX were assessed in rats, mice, and human cardiomyocytes in vitro. Hemodynamic alterations were measured in rats and mice and cardiac enzymes were measured in rats. Primary cultures of neonatal rat ventricular myocytes were treated with TMX and the effects on cell size were measured

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