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methods: plasma samples were analyzed using lc-ms/ms. all samples were anonymized prior to analysis, and the study design did not allow for identification of any participant. lc-ms/ms analysis was performed on samples from all participants using the lc-ms/ms system consisting of a surveyor liquid chromatography (thermo-fisher) coupled with a tsq vantage mass spectrometer (thermo-fisher). the method is based on protein precipitation using methanol; separation of the analytes nic and cit was achieved by elution from a c18 column (partition column luna omega 1.9 µm, 50 x 2.0 mm). analytes were detected by positive electrospray ionization in a full-scan mode. the flow rate was 0.5 ml/min with a 50:50 mixture of acetonitrile/water as solvent. the mass spectrometer was equipped with an hesi probe. the following parameters were used for the sample analysis: a positive ionization voltage of 30 v, a capillary temperature of 320 °c, and a sheath gas flow rate of 30 ml/min.
discussion: the results of the present study suggest that nic metabolism may be associated with the daily number of cigarettes smoked. the most likely explanation for the observed association between daily smoking and nic metabolism may be the overall altered metabolism due to smoking, as observed in chronic smokers.
a data-driven approach to advance the understanding of hemiparesis. motor control in the brain can be thought of as the activity of a neural network that coordinates different muscles and joints, and drives the desired movement. the neural network consists of different sets of neurons: motor neurons, interneurons, and sensorimotor neurons. we believe that by understanding the basic principles of the motor control system we may be able to improve rehabilitation of patients who suffer a hemiparesis, or stroke.
kenotic heresy is a term used in some forms of christianity to refer to systems of belief within christianity that are considered heretical by the others. this article considers three major ascetic movements, the primitive eucharistic, the charismatic movement and the spirit-filled movement. we include some brief discussion of similar ascetic movements in christianity, judaism, islam, and other faiths.
over the period of the preceding 50 years or so, the christian church has moved away from rigid ritual form and toward a more flexible emphasis on theology and the sacraments. this has been accompanied by less emphasis on a deep understanding of the sacraments, both on the part of the laity and the clergy.
kenotic heresy is most commonly associated with the movement of charismatic theology. the eucharist is the most prominent feature of this movement. it is through this sacrament that the believer is believed to be united to the body of christ. this is most clearly evidenced by the eucharist after the consecration of the bread and wine. the church believes that those receiving the eucharist in this manner are partaking of the body of christ and are united to him.
it is this act of consumption that the kenotic heresy believes is the means by which christ is truly present in the communicant. this has led to a number of “attributes” of the traditional eucharist that are no longer traditionally held to be of the eucharist. these are primarily extensions of christ’s “real presence” – a belief that the body and blood of christ are literally present in the elements of the eucharist. eucharistic worship is thus seen to exist in a direct correlation to the body and blood of christ. this worship is achieved through prayer, a deep understanding of the elements of the eucharist, and (in an attempt to be an icon of christ himself) conforming to a specific way of living. this way of worship is seen as a direct reflection of the way christ lived.